She first used the pseudonym George Eliott in a serial for Blackwood's Magazine in 1857 titled The Scenes of Clerical Life. She next produced the great novel Adam Bele (1859),then The Mill on the Floss (1860) and Silas Marner ( 1861).

Later novels Romola (1862-3), Felix Holt (1866) and Middlemarch (1871-2) well display her breadth of knowledge.